Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
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Bywater, Megan J.; Hannan, Ross; Poortinga, Gretchen; Sanij, Elaine; Peck, Abigail; Cullinane, C; Wall, Meaghan; Cluse, Leonie A.; Drygin, Denis; Anderes, Kenna; Huser, Nanni; Proffitt, Chris; Bliesath, Joshua; Haddach, Mustapha; Schwaebe, Michael K; Ryckman, David M; Rice, William G; Schmitt, Clemens; Lowe, Scott W.; Johnstone, Ricky; Pearson, Richard B; McArthur, Grant; Hein, Nadine
Description
Increased transcription of ribosomal RNA genes (rDNA) by RNA Polymerase I is a common feature of human cancer, but whether it is required for the malignant phenotype remains unclear. We show that rDNA transcription can be therapeutically targeted with the small molecule CX-5461 to selectively kill B-lymphoma cells in vivo while maintaining a viable wild-type B cell population. The therapeutic effect is a consequence of nucleolar disruption and activation of p53-dependent apoptotic signaling....[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/67174 |
Source: | Cancer Cell |
DOI: | 10.1016/j.ccr.2012.05.019 |
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01_Bywater_Inhibition_of_RNA_Polymerase_I_2012.pdf | 2.52 MB | Adobe PDF | Request a copy |
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