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Binding modes and functional surface of anti-mammalian scorpion α-toxins to sodium channels

Chen, Rong; Chung, Shin-Ho


Scorpion α-toxins bind to the voltage-sensing domains of voltage-gated sodium (NaV) channels and interfere with the inactivation mechanisms. The functional surface of α-toxins has been shown to contain an NC-domain consisting of the five-residue turn (p

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Biochemistry
DOI: 10.1021/bi300776g


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