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Dysregulation of RNA polymerase I transcription during disease

Hannan, Katherine; Sanij, Elaine; Rothblum, Lawrence I.; Hannan, Ross; Pearson, Richard B


Transcription of the ribosomal RNA genes by the dedicated RNA polymerase I enzyme and subsequent processing of the ribosomal RNA are fundamental control steps in the synthesis of functional ribosomes.Dysregulation of Pol I transcription and ribosome biogenesis is linked to the etiology of a broad range of human diseases. Diseases caused by loss of function mutations in the molecular constituents of the ribosome, or factors intimately associated with RNA polymerase I transcription and processing...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
DOI: 10.1016/j.bbagrm.2012.10.014


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