Dysregulation of RNA polymerase I transcription during disease
Transcription of the ribosomal RNA genes by the dedicated RNA polymerase I enzyme and subsequent processing of the ribosomal RNA are fundamental control steps in the synthesis of functional ribosomes.Dysregulation of Pol I transcription and ribosome biogenesis is linked to the etiology of a broad range of human diseases. Diseases caused by loss of function mutations in the molecular constituents of the ribosome, or factors intimately associated with RNA polymerase I transcription and processing...[Show more]
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|Source:||Biochimica et Biophysica Acta - Gene Regulatory Mechanisms|
|01_Hannan_Dysregulation_of_RNA_2013.pdf||759.6 kB||Adobe PDF||Request a copy|
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