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The mTORC1 inhibitor everolimus prevents and treats E?-Myc lymphoma by restoring oncogene-induced senescence

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Wall, Meaghan; Poortinga, Gretchen; Stanley, Kym L.; Lindemann, Ralph K.; Bots, Michael; Chan, Christopher J; Bywater, Megan J.; Kinross, Kathryn M.; Astle, Megan V.; Waldeck, Kelly; Hannan, Katherine; Shortt, Jake; Smyth, Mark J; Lowe, Scott W.; Hannan, Ross; Pearson, Richard B; Johnstone, Ricky; McArthur, Grant

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MYC deregulation is common in human cancer. IG-MYC translocations that are modeled in EμMyc mice occur in almost all cases of Burkitt lymphoma as well as in other B-cell lymphoproliferative disorders. Deregulated expression of MYC results in increased mT

dc.contributor.authorWall, Meaghan
dc.contributor.authorPoortinga, Gretchen
dc.contributor.authorStanley, Kym L.
dc.contributor.authorLindemann, Ralph K.
dc.contributor.authorBots, Michael
dc.contributor.authorChan, Christopher J
dc.contributor.authorBywater, Megan J.
dc.contributor.authorKinross, Kathryn M.
dc.contributor.authorAstle, Megan V.
dc.contributor.authorWaldeck, Kelly
dc.contributor.authorHannan, Katherine
dc.contributor.authorShortt, Jake
dc.contributor.authorSmyth, Mark J
dc.contributor.authorLowe, Scott W.
dc.contributor.authorHannan, Ross
dc.contributor.authorPearson, Richard B
dc.contributor.authorJohnstone, Ricky
dc.contributor.authorMcArthur, Grant
dc.date.accessioned2015-12-10T23:24:19Z
dc.identifier.issn2159-8290
dc.identifier.urihttp://hdl.handle.net/1885/67129
dc.description.abstractMYC deregulation is common in human cancer. IG-MYC translocations that are modeled in EμMyc mice occur in almost all cases of Burkitt lymphoma as well as in other B-cell lymphoproliferative disorders. Deregulated expression of MYC results in increased mT
dc.publisherAmerican Association for Cancer Research
dc.sourceCancer Discovery
dc.subjectKeywords: etoposide; everolimus; Myc protein; placebo; protein p53; animal cell; animal experiment; animal model; animal tissue; article; B lymphocyte; bone marrow; cancer specific survival; cell cycle; cell differentiation; cell transformation; controlled study; f
dc.titleThe mTORC1 inhibitor everolimus prevents and treats E?-Myc lymphoma by restoring oncogene-induced senescence
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume3
dc.date.issued2013
local.identifier.absfor111201 - Cancer Cell Biology
local.identifier.absfor111207 - Molecular Targets
local.identifier.absfor111206 - Haematological Tumours
local.identifier.ariespublicationa383154xPUB1403
local.type.statusPublished Version
local.contributor.affiliationWall, Meaghan, Victorian Cancer Cytogenetics Service
local.contributor.affiliationPoortinga, Gretchen, Peter MacCalllum Cancer Centre
local.contributor.affiliationStanley, Kym L., Peter MacCallum Cancer Centre
local.contributor.affiliationLindemann, Ralph K., Peter MacCallum Cancer Centre
local.contributor.affiliationBots, Michael, Peter MacCallum Cancer Centre
local.contributor.affiliationChan, Christopher J, Peter MacCallum Cancer Centre
local.contributor.affiliationBywater, Megan J., Peter MacCallum Cancer Centre
local.contributor.affiliationKinross, Kathryn M., Peter MacCallum Cancer Centre
local.contributor.affiliationAstle, Megan V., Peter MacCallum Cancer Centre
local.contributor.affiliationWaldeck, Kelly, Peter MacCallum Cancer Centre
local.contributor.affiliationHannan, Katherine, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationShortt, Jake, Peter MacCallum Cancer Centre
local.contributor.affiliationSmyth, Mark J, Peter MacCallum Cancer Centre
local.contributor.affiliationLowe, Scott W., Cold Spring Harbor Laboratory
local.contributor.affiliationHannan, Ross, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationPearson, Richard B, Peter MacCallum Cancer Centre
local.contributor.affiliationJohnstone, Ricky, Peter MacCallum Cancer Centre
local.contributor.affiliationMcArthur, Grant, Peter MacCallum Cancer Centre
local.description.embargo2037-12-31
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage82
local.bibliographicCitation.lastpage95
local.identifier.doi10.1158/2159-8290.CD-12-0404
dc.date.updated2016-02-24T08:04:58Z
local.identifier.scopusID2-s2.0-84872857051
CollectionsANU Research Publications

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