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The mTORC1 inhibitor everolimus prevents and treats E?-Myc lymphoma by restoring oncogene-induced senescence

Wall, Meaghan; Poortinga, Gretchen; Stanley, Kym L.; Lindemann, Ralph K.; Bots, Michael; Chan, Christopher J; Bywater, Megan J.; Kinross, Kathryn M.; Astle, Megan V.; Waldeck, Kelly; Hannan, Katherine; Shortt, Jake; Smyth, Mark J; Lowe, Scott W.; Hannan, Ross; Pearson, Richard B; Johnstone, Ricky; McArthur, Grant


MYC deregulation is common in human cancer. IG-MYC translocations that are modeled in EμMyc mice occur in almost all cases of Burkitt lymphoma as well as in other B-cell lymphoproliferative disorders. Deregulated expression of MYC results in increased mT

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Cancer Discovery
DOI: 10.1158/2159-8290.CD-12-0404


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