Dynamic evolution of venom proteins in squamate reptiles
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Casewell, Nicholas; Huttley, Gavin Austin; Wuster, Wolfgang
Description
Phylogenetic analyses of toxin gene families have revolutionised our understanding of the origin and evolution of reptile venoms, leading to the current hypothesis that venom evolved once in squamate reptiles. However, because of a lack of homologous squamate non-toxin sequences, these conclusions rely on the implicit assumption that recruitments of protein families into venom are both rare and irreversible. Here we use sequences of homologous non-toxin proteins from two snake species to test...[Show more]
dc.contributor.author | Casewell, Nicholas | |
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dc.contributor.author | Huttley, Gavin Austin | |
dc.contributor.author | Wuster, Wolfgang | |
dc.date.accessioned | 2015-12-10T23:24:10Z | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/1885/67119 | |
dc.description.abstract | Phylogenetic analyses of toxin gene families have revolutionised our understanding of the origin and evolution of reptile venoms, leading to the current hypothesis that venom evolved once in squamate reptiles. However, because of a lack of homologous squamate non-toxin sequences, these conclusions rely on the implicit assumption that recruitments of protein families into venom are both rare and irreversible. Here we use sequences of homologous non-toxin proteins from two snake species to test these assumptions. Phylogenetic and ancestral-state analyses revealed frequent nesting of 'physiological' proteins within venom toxin clades, suggesting early ancestral recruitment into venom followed by reverse recruitment of toxins back to physiological roles. These results provide evidence that protein recruitment into venoms from physiological functions is not a one-way process, but dynamic, with reversal of function and/or co-expression of toxins in different tissues. This requires a major reassessment of our previous understanding of how animal venoms evolve. | |
dc.publisher | Macmillan Publishers Ltd | |
dc.rights | Author/s retain copyright | |
dc.source | Nature Communications | |
dc.subject | Keywords: toxin; venom; amino acid sequence; article; monophyly; nonhuman; phylogeny; protein expression; squamate; Animals; Evolution, Molecular; Phylogeny; Reptiles; Reptilian Proteins; Snakes; Venoms; Animalia; Reptilia | |
dc.title | Dynamic evolution of venom proteins in squamate reptiles | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 3 | |
dc.date.issued | 2012 | |
local.identifier.absfor | 060409 - Molecular Evolution | |
local.identifier.absfor | 060102 - Bioinformatics | |
local.identifier.ariespublication | f5625xPUB1401 | |
local.type.status | Published Version | |
local.contributor.affiliation | Casewell, Nicholas, Liverpool School of Tropical Medicine | |
local.contributor.affiliation | Huttley, Gavin Austin, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Wuster, Wolfgang, University of Bangor | |
local.bibliographicCitation.startpage | 1 | |
local.bibliographicCitation.lastpage | 10 | |
local.identifier.doi | 10.1038/ncomms2065 | |
local.identifier.absseo | 960809 - Mining Flora, Fauna and Biodiversity | |
local.identifier.absseo | 920199 - Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified | |
local.identifier.absseo | 970106 - Expanding Knowledge in the Biological Sciences | |
dc.date.updated | 2016-02-24T08:46:12Z | |
local.identifier.scopusID | 2-s2.0-84867001732 | |
local.identifier.thomsonID | 000309338100033 | |
dcterms.accessRights | Open Access | |
Collections | ANU Research Publications |
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