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Indomethacin administered early in the postnatal period results in reduced glomerular number in the adult rat

Kent, Alison; Koina, Mark; Gubhaju, Lina; Cullen-McEwen, L. A.; Bertram, John; Lynnhtun, J.; Shadbolt, Bruce; Falk, Michael; Dahlstrom, Jane


Indomethacin and ibuprofen are administered to close a patent ductus arteriosus (PDA) during active glomerulogenesis. Light and electron microscopic glomerular changes with no change in glomerular number were seen following indomethacin and ibuprofen treatment during glomerulogenesis at 14 days after birth in a neonatal rat model. This present study aimed to determine whether longstanding renal structural changes are present at 30 days and 6 mo (equivalent to human adulthood). Rat pups were...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: American Journal of Physiology: Renal Physiology
DOI: 10.1152/ajprenal.00328.2014


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