Indomethacin administered early in the postnatal period results in reduced glomerular number in the adult rat
Indomethacin and ibuprofen are administered to close a patent ductus arteriosus (PDA) during active glomerulogenesis. Light and electron microscopic glomerular changes with no change in glomerular number were seen following indomethacin and ibuprofen treatment during glomerulogenesis at 14 days after birth in a neonatal rat model. This present study aimed to determine whether longstanding renal structural changes are present at 30 days and 6 mo (equivalent to human adulthood). Rat pups were...[Show more]
|Collections||ANU Research Publications|
|Source:||American Journal of Physiology: Renal Physiology|
|01_Kent_Indomethacin_administered_2014.pdf||3.02 MB||Adobe PDF|
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