Niemand, J; Louw, A I; Birkholtz, L; Kirk, Kiaran
Polyamines and the enzymes involved in their biosynthesis are present at high levels in rapidly proliferating cells, including cancer cells and protozoan parasites. Inhibition of polyamine biosynthesis in asexual blood-stage malaria parasites causes cytostatic arrest of parasite development under in vitro conditions, but does not cure infections in vivo. This may be due to replenishment of the parasite's intracellular polyamine pool via salvage of exogenous polyamines from the host. However,...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.