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Polyamine uptake by the intraerythrocytic malaria parasite, Plasmodium falciparum

Niemand, J; Louw, A I; Birkholtz, L; Kirk, Kiaran


Polyamines and the enzymes involved in their biosynthesis are present at high levels in rapidly proliferating cells, including cancer cells and protozoan parasites. Inhibition of polyamine biosynthesis in asexual blood-stage malaria parasites causes cytostatic arrest of parasite development under in vitro conditions, but does not cure infections in vivo. This may be due to replenishment of the parasite's intracellular polyamine pool via salvage of exogenous polyamines from the host. However,...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: International Journal for Parasitology
DOI: 10.1016/j.ijpara.2012.07.005


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