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Targeting the nucleolus for cancer intervention

Quin, Jaclyn; Devlin, Jennifer; Cameron, Donald; Hannan, Katherine; Pearson, Richard B; Hannan, Ross

Description

The contribution of the nucleolus to cancer is well established with respect to its traditional role in facilitating ribosome biogenesis and proliferative capacity. More contemporary studies however, infer that nucleoli contribute a much broader role in malignant transformation. Specifically, extra-ribosomal functions of the nucleolus position it as a central integrator of cellular proliferation and stress signaling, and are emerging as important mechanisms for modulating how oncogenes and...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/66844
Source: Biochimica et Biophysica Acta - Molecular Basis of Disease
DOI: 10.1016/j.bbadis.2013.12.009

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