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Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes

Hoyne, Gerard; Flening, Eleanor; Yabas, Mehmet; Teh, Charis; Altin, John; Randall, Katrina; Thien, Christine B.F.; Langdon, Wallace; Goodnow, Christopher

Description

The E3 ubiquitin ligase Cbl-b regulates T cell activation thresholds and has been associated with protecting against type 1 diabetes, but its invivo role in the process of self-tolerance has not been examined at the level of potentially autoaggressive CD4+ T cells. In this study, we visualize the consequences of Cbl-b deficiency on self-tolerance to lysozyme Ag expressed in transgenic mice under control of the insulin promoter (insHEL). By tracing the fate of pancreatic islet-reactive CD4+ T...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/66821
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1002296

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