Hoyne, Gerard; Flening, Eleanor; Yabas, Mehmet; Teh, Charis; Altin, John; Randall, Katrina; Thien, Christine B.F.; Langdon, Wallace; Goodnow, Christopher
The E3 ubiquitin ligase Cbl-b regulates T cell activation thresholds and has been associated with protecting against type 1 diabetes, but its invivo role in the process of self-tolerance has not been examined at the level of potentially autoaggressive CD4+ T cells. In this study, we visualize the consequences of Cbl-b deficiency on self-tolerance to lysozyme Ag expressed in transgenic mice under control of the insulin promoter (insHEL). By tracing the fate of pancreatic islet-reactive CD4+ T...[Show more]
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