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Platelets and P-Selectin Control Tumor Cell Metastasis in an Organ-Specific Manner and Independently of NK Cells

Coupland, Lucy; Chong, Beng; Parish, Christopher


The prometastatic role of platelets has long been recognized with proposed mechanisms of action including shielding tumor cells from natural killer (NK) cell destruction and aiding endothelial attachment and extravasation of tumor cells with platelet P-selectin being implicated in these processes. However, many aspects of the prometastatic function of platelets remain unclear. In this study, we used mouse models of metastatic breast cancer and melanoma to investigate the platelet effect,...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Cancer Research
DOI: 10.1158/0008-5472.CAN-11-4010


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