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Interaction anisotropy and shear instability of aspirin polymorphs established by nanoindentation

Varughese, S; Mangalampalli, S.R.N. Kiran; Solanko, Katarzyna A.; Bond, Andrew D.; Ramamurty, U; Desiraju, G R


Nanoindentation is applied to the two polymorphs of aspirin to examine and differentiate their interaction anisotropy and shear instability. Aspirin provides an excellent test system for the technique because: (i) polymorphs I and II exhibit structural similarity in two dimensions, thereby facilitating clear examination of the differences in mechanical response in relation to well-defined differences between the two crystal structures; (ii) single crystals of the metastable polymorph II have...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Chemical Science
DOI: 10.1039/c1sc00430a


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