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Proteolysis of human hemoglobin by schistosome cathepsin D

Brindley, Paul J; Kalinna, Bernd; Wong, Joanna Y M; Bogitsh, Burton; King, Lynette J; Smyth, Danielle J; Verity, Christiana K; Abbenante, Giovanni; Brinkworth, Ross I; Fairlie, David P; Smythe, Mark L; Milburn, Peter J; Bielefeldt-Ohmann, Helle; Zheng, Yuan; McManus, Donald P


Schistosomes feed on human blood. They employ proteases to degrade hemoglobin from ingested erythrocytes, using the residues released for amino acid metabolism. However, the identity and the role of the participating protease(s) are unclear and controversial. Confocal microscopy localized schistosomal cathepsin D to the parasite gastrodermis, and revealed elevated protease expression in females. At sub-cellular level, cathepsin D was localized to superficial digestive vacuoles of the gut and to...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Molecular and Biochemical Parasitology
DOI: 10.1016/S0166-6851(00)00351-0


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