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Two layers of synaptic processing by principal neurons in piriform cortex

Suzuki, Norimitsu; Bekkers, John

Description

The primary olfactory (or piriform) cortex is a trilaminar paleocortex that is thought to construct unified "odor images" from the odor components identified by the olfactory bulb. How the piriform cortex (PC) accomplishes this sophisticated synthetic task, despite its relatively simple architecture, is unknown. Here we used in vitro patch-clamp recordings from acute slices of the anterior PC of mice to identify microcircuits involved in excitatory synaptic processing. Cluster analysis...[Show more]

dc.contributor.authorSuzuki, Norimitsu
dc.contributor.authorBekkers, John
dc.date.accessioned2015-12-10T23:22:49Z
dc.identifier.issn0270-6474
dc.identifier.urihttp://hdl.handle.net/1885/66680
dc.description.abstractThe primary olfactory (or piriform) cortex is a trilaminar paleocortex that is thought to construct unified "odor images" from the odor components identified by the olfactory bulb. How the piriform cortex (PC) accomplishes this sophisticated synthetic task, despite its relatively simple architecture, is unknown. Here we used in vitro patch-clamp recordings from acute slices of the anterior PC of mice to identify microcircuits involved in excitatory synaptic processing. Cluster analysis confirmed the presence of two prominent classes of glutamatergic principal cells in the main input layer (layer II) of the PC: semilunar (SL) cells and superficial pyramidal (SP) cells. SL cells received stronger afferent excitatory input from the olfactory bulb, on average, than did SP cells. This was due to the larger mean strength of single-fiber afferents onto SL cells. In contrast, SP cells received stronger associational (intracortical) excitatory inputs, most likely due to their more extensive dendritic trees within the associational layers. Tissue-cut experiments and dual recordings from SL and SP cells in disinhibited slices were consistent with the distinctive patterns of connectivity of these two cell classes. Our findings suggest that the anterior PC employs at least two layers of excitatory synaptic processing: one involving strong afferent inputs onto SL cells, and another involving strong intracortical inputs onto SP cells. This architecture may allow the PC to sequentially process olfactory information within segregated subcircuits.
dc.publisherSociety for Neuroscience
dc.rightsAuthor/s retain copyright
dc.sourceJournal of Neuroscience
dc.subjectKeywords: action potential; animal cell; article; brain nerve cell; cluster analysis; controlled study; cytoarchitecture; dendrite; evoked response; membrane steady potential; mouse; nerve cell excitability; nonhuman; olfactory bulb; patch clamp; priority journal;
dc.titleTwo layers of synaptic processing by principal neurons in piriform cortex
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume31
dc.date.issued2011
local.identifier.absfor110902 - Cellular Nervous System
local.identifier.ariespublicationf2965xPUB1325
local.type.statusPublished Version
local.contributor.affiliationSuzuki, Norimitsu, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBekkers, John, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue6
local.bibliographicCitation.startpage2156
local.bibliographicCitation.lastpage2166
local.identifier.doi10.1523/JNEUROSCI.5430-10.2011
dc.date.updated2016-02-24T08:12:37Z
local.identifier.scopusID2-s2.0-79951544356
local.identifier.thomsonID000287389400023
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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