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Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo

Fossat, Nicolas; Jones, Vanessa; Khoo, Poh-Lynn; Bogani, Debora; Hardy, Andrea; Steiner, Kirsten; Mukhopadhyay, Mahua; Westphal, Heiner; Nolan, Patrick; Arkell, Ruth; Tam, Patrick

Description

In mouse embryos, loss of Dickkopf-1 (DKK1) activity is associated with an ectopic activation of WNT signalling responses in the precursors of the craniofacial structures and leads to a complete truncation of the head at early organogenesis. Here, we show that ENU-induced mutations of genes coding for two WNT canonical pathway factors, the co-receptor LRP6 and the transcriptional co-activator β-catenin, also elicit an ectopic signalling response and result in loss of the rostral tissues of the...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/66666
Source: Development
DOI: 10.1242/dev.052803

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