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Detection of bacterial DNA in lymph nodes of Crohn's disease patients using high throughput sequencing

O'Brien, Claire; Pavli, Paul; Gordon, David; Allison, Gwen


Our aim was to determine whether or not specific microorganisms were transported selectively to lymph nodes in Crohn's disease (CD) by comparing node and mucosal microbial communities in patients and controls. We also sought evidence of dysbiosis and bacterial translocation. Lymph nodes, and involved and uninvolved mucosal samples were obtained from resections of 58 patients (29 CD, eight 'other inflammatory bowel disease' (IBD) and 21 non-IBD). Universal primers targeting V1-V3 regions of...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Gut
DOI: 10.1136/gutjnl-2013-305320


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