Saito, Hiroko; Matsumoto, Koichiro; Denburg, Avram; Crawford, Lynn; Ellis, Russ; Inman, Mark; Sehmi, Roma; Takatsu, Kiyoshi; Matthaei, Klaus; Denburg, Judah
Recent studies have demonstrated an important role for IL-5-dependent bone marrow eosinophil progenitors in allergic inflammation. However, studies using anti-IL-5 mAbs in human asthmatics have failed to suppress lower airway hyperresponsiveness despite suppression of eosinophilia; therefore, it is critical to examine the role of IL-5 and bone marrow responses in the pathogenesis of allergic airway disease. To do this, we studied the effects of IL-5 deficiency (IL-5-/-) on bone marrow function...[Show more]
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