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Evidence of hematopoietic differentiation, vasculogenesis and angiogenesis in the formation of human choroidal blood vessels

Chan-Ling, Tailoi; Koina, Mark; McColm, Janet; Sterling, Ruth-Ann; Bean, Elaine; Adamson, Sam; Hughes, Suzanne; Baxter, Louise; Dahlstrom, Jane


Human fetal eyes 8-40 weeks gestation (WG) were examined using markers to hematopoietic stem cells (HSC), vascular precursor cells (VPC), monocytes/macrophages and endothelial cells (EC). Electron microscopy and bromo-deoxyuridene labeling were undertaken to confirm the existence of solid vascular cords and to demonstrate vasculogenesis and angiogenesis in developing choroidal tissue. Our results demonstrated that the earliest incipient choroid consisted of vimentin+ mesenchymal precursor cells...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Experimental Eye Research
DOI: 10.1016/j.exer.2011.02.009


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