The neuropsychiatry of neuroacanthocytosis syndromes
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Walterfang, Mark; Evans, Andrew; Looi, Jeffrey; Jung, Hans H; Danek, Adrian; Walker, Ruth H; Velakoulis, Dennis
Description
The neuroacanthocytoses are a group of disorders characterised by peripheral blood acanthocytes, central nervous system as well as neuromuscular symptoms. These disorders uniformly result in pathology in the basal ganglia, which account for the characteristic motor symptoms such as chorea or dystonia, but may also account for the apparent elevated rates of major mental disorders in these syndromes. Elevated rates of dysexecutive syndromes, obsessive-compulsive disorder, depression and...[Show more]
dc.contributor.author | Walterfang, Mark | |
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dc.contributor.author | Evans, Andrew | |
dc.contributor.author | Looi, Jeffrey | |
dc.contributor.author | Jung, Hans H | |
dc.contributor.author | Danek, Adrian | |
dc.contributor.author | Walker, Ruth H | |
dc.contributor.author | Velakoulis, Dennis | |
dc.date.accessioned | 2015-12-10T23:20:25Z | |
dc.identifier.issn | 0149-7634 | |
dc.identifier.uri | http://hdl.handle.net/1885/66318 | |
dc.description.abstract | The neuroacanthocytoses are a group of disorders characterised by peripheral blood acanthocytes, central nervous system as well as neuromuscular symptoms. These disorders uniformly result in pathology in the basal ganglia, which account for the characteristic motor symptoms such as chorea or dystonia, but may also account for the apparent elevated rates of major mental disorders in these syndromes. Elevated rates of dysexecutive syndromes, obsessive-compulsive disorder, depression and schizophrenia-like psychosis appear to occur in chorea-acanthocytosis, McLeod's syndrome, pantothenate kinase-associated neurodegeneration, and Huntington's disease-like 2. Disruptions to key frontostriatal loops secondary to pathology in the striatum and pallidum appear to predispose individuals to major neuropsychiatric syndromes; however, treatment can be instituted for a number of these manifestations, which lessens the overall burden of disease in neuroacanthocytosis patients and their families. | |
dc.publisher | Elsevier | |
dc.source | Neuroscience and Biobehavioral Reviews | |
dc.subject | Keywords: aripiprazole; atypical antipsychotic agent; chlorpromazine; clozapine; dopamine receptor blocking agent; haloperidol; neuroleptic agent; olanzapine; quetiapine; risperidone; serotonin uptake inhibitor; thioridazine; trifluoperazine; adjuvant therapy; anti Chorea-acanthocytosis; Executive impairment; McLeod syndrome; Neuroacanthocytosis; Obsessive-compulsive disorder; Schizophrenia; Striatum | |
dc.title | The neuropsychiatry of neuroacanthocytosis syndromes | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 35 | |
dc.date.issued | 2011 | |
local.identifier.absfor | 110904 - Neurology and Neuromuscular Diseases | |
local.identifier.ariespublication | f2965xPUB1263 | |
local.type.status | Published Version | |
local.contributor.affiliation | Walterfang, Mark, Royal Melbourne Hospital | |
local.contributor.affiliation | Evans, Andrew, Royal Melbourne Hospital | |
local.contributor.affiliation | Looi, Jeffrey, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Jung, Hans H, University Hospital Zurich | |
local.contributor.affiliation | Danek, Adrian, Ludwig-Maximilians Universitat | |
local.contributor.affiliation | Walker, Ruth H, Mount Sinai School of Medicine | |
local.contributor.affiliation | Velakoulis, Dennis, Royal Melbourne Hospital | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 5 | |
local.bibliographicCitation.startpage | 1275 | |
local.bibliographicCitation.lastpage | 1283 | |
local.identifier.doi | 10.1016/j.neubiorev.2011.01.001 | |
local.identifier.absseo | 970111 - Expanding Knowledge in the Medical and Health Sciences | |
dc.date.updated | 2016-02-24T08:11:21Z | |
local.identifier.scopusID | 2-s2.0-79952537096 | |
local.identifier.thomsonID | 000289337500015 | |
Collections | ANU Research Publications |
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