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The evolution of genomic imprinting: costs, benefits and long-term consequences

Holman, Luke; Kokko, Hanna

Description

Genomic imprinting refers to a pattern of gene expression in which a specific parent's allele is either under-expressed or completely silenced. Imprinting is an evolutionary conundrum because it appears to incur the costs of diploidy (e.g. presenting a larger target than haploidy to mutations) while foregoing its benefits (protection from harmful recessive mutations). Here, we critically evaluate previously proposed evolutionary benefits of imprinting and suggest some additional ones. We...[Show more]

dc.contributor.authorHolman, Luke
dc.contributor.authorKokko, Hanna
dc.date.accessioned2015-12-10T23:20:11Z
dc.identifier.issn1464-7931
dc.identifier.urihttp://hdl.handle.net/1885/66209
dc.description.abstractGenomic imprinting refers to a pattern of gene expression in which a specific parent's allele is either under-expressed or completely silenced. Imprinting is an evolutionary conundrum because it appears to incur the costs of diploidy (e.g. presenting a larger target than haploidy to mutations) while foregoing its benefits (protection from harmful recessive mutations). Here, we critically evaluate previously proposed evolutionary benefits of imprinting and suggest some additional ones. We discuss whether each benefit is capable of explaining both the origin and maintenance of imprinting, and examine how the different benefits interact. We then outline the many costs of imprinting. Simple models show that circulating deleterious recessives can prevent the initial spread of imprinting, even if imprinting would be evolutionarily stable if it could persist long enough to purge these. We also show that imprinting can raise or lower the mutation load, depending on the selective regime and the degree of dominance. We finish by discussing the population-level consequences of imprinting, which can be both positive and negative. Imprinting offers many insights into evolutionary conflict, the interaction between individual- and population-level fitness effects, and the 'gene's-eye view' of evolution. Biological Reviews
dc.publisherCambridge University Press
dc.sourceBiological Reviews
dc.titleThe evolution of genomic imprinting: costs, benefits and long-term consequences
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume89
dc.date.issued2014
local.identifier.absfor060399 - Evolutionary Biology not elsewhere classified
local.identifier.ariespublicationu9511635xPUB1243
local.type.statusPublished Version
local.contributor.affiliationHolman, Luke, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKokko, Hanna, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue3
local.bibliographicCitation.startpage568
local.bibliographicCitation.lastpage587
local.identifier.doi10.1111/brv.12069
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2015-12-10T10:21:13Z
local.identifier.scopusID2-s2.0-84903155651
local.identifier.thomsonID000339562900004
CollectionsANU Research Publications

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