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Short-Term Therapy with Peroxisome Proliferation-Activator Receptor-Agonist Wy-14,643 Protects Murine Fatty Liver Against Ischemia-Reperfusion Injury

Teoh, Narcissus; Williams, Jacqueline; Hartley, Jennifer; Yu, Jun; McCuskey, Robert; Farrell, Geoffrey


Steatosis increases operative morbidity/mortality from ischemia-reperfusion injury (IRI); few pharmacological approaches have been protective. Using novel genetic/dietary models of nonalcoholic steatohepatitis (NASH) and simple steatosis (SS) in Alms1 mutant (foz/foz) mice, we characterized severity of IRI in NASH versus SS and lean liver and tested our hypothesis that the lipid-lowering effects of the peroxisome proliferation-activator receptor (PPAR)-agonist Wy-14,643 would be...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Hepatology
DOI: 10.1002/hep.23420


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