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Heme Oxygenase-1 Protects Against Steatohepatitis in Both Cultured Hepatocytes and Mice

Yu, Jun; Chu, Eagle S. H.; Wang, Ruizhi; Wang, Shiyan; Wu, Chung W.; Wong, Vincent; Chan, Henry L. Y.; Farrell, Geoffrey; Sung, Joseph J. Y.


Background & Aims: Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced tissue injury. We investigated the role of HO-1 in nutritional steatohepatitis in vitro and in vivo. Methods: AML-12 hepatocytes were cultured in methionine- and choline-deficient (MCD) medium. Cells were transfected with an adenovirus vector that expressed HO-1 (Ad-HO-1) or incubated with the HO-1 inducer hemin or the HO-1 inhibitor stannic mesoporphyrin for 24 hours....[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Gastroenterology
DOI: 10.1053/j.gastro.2009.09.058


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