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Cardiac troponin may be released by ischemia alone, without necrosis

Hickman, Peter; Potter, Julia; Aroney, Con; Koerbin, Gus; Southcott, Emma K; Wu, Allan; Roberts, M

Description

Whilst it is formally stated that cardiac troponin is only released when cardiac myocytes undergo necrosis, there are a number of clinical situations where troponin is present in the circulation, without any apparent cardiac injury. In these cases, troponin half-life in the circulation is usually substantially shorter than that seen when troponin is released following myocardial infarction with frank necrosis. A mechanism has been described in liver, where large cytoplasmic molecules can pass...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/66029
Source: Clinica Chimica Acta
DOI: 10.1016/j.cca.2009.12.009

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