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The yeast homolog of heme oxygenase-1 affords cellular antioxidant protection via the transcriptional regulation of known antioxidant genes

Collison, Emma J; Wimmer-Kleikamp, Sabine; Gerega, Sebastian K.; Yang, Lee Hwa; Dawes, Ian William; Stocker, Roland; Parish, Christopher


Heme oxygenase-1 (HO-1) degrades heme and protects cells from oxidative challenge. This antioxidant activity is thought to result from the HO-1 enzymatic activity, manifested by Abstract decrease in the concentration of the pro-oxidant substrate heme, and an increase in the antioxidant product bilirubin. Using a global transcriptional approach, and yeast as a model, we show that HO-1 affords cellular protection via up-regulation of transcripts encoding enzymes involved in cellular antioxidant...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M110.187062
Access Rights: Open Access


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