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CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-Driven MARCH1-mediated ubiquitination and degradation

Tze, Lina; Horikawa, Keisuke; Domaschenz, Heather; Howard, Debbie; Roots, Carla; Rigby, Robert; Way, David; Ohmura-Hoshino, Maria; Ishido, Satoshi; Andoniou, Christopher E; Degli-Esposti, Mariapia A; Goodnow, Christopher


Effective vaccine adjuvants must induce expression of major histocompatability (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells (DCs). However, some adjuvants elicit production of cytokines resulting in adverse inflammatory consequences. Development of agents that selectively increase MHC class II and CD86 expression without triggering unwanted cytokine production requires a better understanding of the molecular mechanisms influencing the production and degradation...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20092203


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