CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-Driven MARCH1-mediated ubiquitination and degradation
Tze, Lina; Horikawa, Keisuke; Domaschenz, Heather; Howard, Debbie; Roots, Carla; Rigby, Robert; Way, David; Ohmura-Hoshino, Maria; Ishido, Satoshi; Andoniou, Christopher E; Degli-Esposti, Mariapia A; Goodnow, Christopher
Effective vaccine adjuvants must induce expression of major histocompatability (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells (DCs). However, some adjuvants elicit production of cytokines resulting in adverse inflammatory consequences. Development of agents that selectively increase MHC class II and CD86 expression without triggering unwanted cytokine production requires a better understanding of the molecular mechanisms influencing the production and degradation...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Experimental Medicine|
|01_Tze_CD83_increases_MHC_II_and_CD86_2011.pdf||4.09 MB||Adobe PDF|
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