A novel role for the pol I transcription factor ubtf in maintaining genome stability through the regulation of highly transcribed pol II genes
Sanji, Elaine; Diesch, Jeannine; Lesmana, Analie; Poortinga, Gretchen; Hein, Nadine; Lidgerwood, Grace; Cameron, Donald; Ellul, Jason; Goodall, Gregory; Wong, Lee H.; Dhillon, Amardeep S.; Hamdane, Nourdine; Rothblum, Lawrence I.; Pearson, Richard B; Haviv, Izhak; Moss, Tom; Hannan, Ross
Mechanisms to coordinate programs of highly transcribed genes required for cellular homeostasis and growth are unclear. Upstream binding transcription factor (UBTF, also called UBF) is thought to function exclusively in RNA polymerase I (Pol I)-specific transcription of the ribosomal genes. Here, we report that the two isoforms of UBTF (UBTF1/2) are also enriched at highly expressed Pol II-transcribed genes throughout the mouse genome. Further analysis of UBTF1/2 DNA binding in immortalized...[Show more]
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