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Channel Activity of Deamidated Isoforms of Prion Protein Fragment 106-126 in Planar Lipid Bilayers

Kourie, Joseph; Farrelly, Peter; Henry, Christine


Using the lipid bilayer technique, we have found that age-related derivatives, PrP[106-126] (L-Asp108) and PrP[106-126] (L-iso-Asp108), of the prion protein fragment 106-126 (PrP[106-126] (Asn108)) form heterogeneous ion channels. The deamidated isoforms, PrP[106-126] (L-Asp108) and PrP[106-126] (L-iso-Asp108), showed no enhanced propensity to form heterogeneous channels compared with PrP[106-126] (Asn108). One of the PrP[106-126] (L-Asp108)- and PrP[106-126] (L-iso-Asp108)-formed channels had...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Neuroscience Research
DOI: 10.1002/jnr.1213


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