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Endocultivation: The influence of delayed vs. simultaneous application of BMP-2 onto individually formed hydroxyapatite matrices for heterotopic bone induction

Becker, Stephan T; Bolte, H; Schunemann, K; Seitz, H; Bara, J J; Beck-Broichsitter, B E; Russo, Paul; Wiltfang, J; Warnke, Patrick H


When bone morphogenetic protein (BMP) is delivered to matrices in vivo may affect tissue engineered bone constructs for jaw reconstruction after cancer surgery. This study compared the effects of BMP application at different times after matrix implantation for heterotopic bone induction in a rat model. Hydroxyapatite blocks were implanted unilaterally onto the surface of the latissimus dorsi muscle. A second block was implanted onto the contralateral muscle after 1, 2 or 4 weeks and 200 μg...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: International Journal of Oral and Maxillofacial Surgery
DOI: 10.1016/j.ijom.2012.03.031


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