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Non-tuberculous mycobacteria have diverse effects on BCG efficacy against Mycobacterium tuberculosis

Poyntz, Hazel C; Stylianou, Elena; Griffiths, Kristin; Marsay, Leanne; Checkley, Anna M; McShane, Helen

Description

The efficacy of Bacillus Calmette-Guerin (BCG) vaccination in protection against pulmonary tuberculosis (TB) is highly variable between populations. One possible explanation for this variability is increased exposure of certain populations to non-tuberculous mycobacteria (NTM). This study used a murine model to determine the effect that exposure to NTM after BCG vaccination had on the efficacy of BCG against aerosol Mycobacterium tuberculosis challenge. The effects of administering live...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/65517
Source: Tuberculosis
DOI: 10.1016/j.tube.2013.12.006

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