Skip navigation
Skip navigation

Random mutagenesis of the mouse genome: A strategy for discovering gene function and the molecular basis of disease

Nguyen, Nhung; Judd, Louise; Kalantzis, Anastasia; Whittle, Belinda; Giraud, Andy; van Driel, Ian


Mutagenesis of mice with N-ethyl-N-nitrosourea (ENU) is a phenotype-driven approach to unravel gene function and discover new biological pathways. Phenotype-driven approaches have the advantage of making no assumptions about the function of genes and their products and have been successfully applied to the discovery of novel gene-phenotype relationships in many physiological systems. ENU mutagenesis of mice is used in many large-scale and more focused projects to generate and identify novel...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: American Journal of Physiology: Gastrointestinal and Liver Physiology
DOI: 10.1152/ajpgi.00343.2010


File Description SizeFormat Image
01_Nguyen_Random_mutagenesis_of_the_2011.pdf1.87 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator