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Random mutagenesis of the mouse genome: A strategy for discovering gene function and the molecular basis of disease

Nguyen, Nhung; Judd, Louise; Kalantzis, Anastasia; Whittle, Belinda; Giraud, Andy; van Driel, Ian

Description

Mutagenesis of mice with N-ethyl-N-nitrosourea (ENU) is a phenotype-driven approach to unravel gene function and discover new biological pathways. Phenotype-driven approaches have the advantage of making no assumptions about the function of genes and their products and have been successfully applied to the discovery of novel gene-phenotype relationships in many physiological systems. ENU mutagenesis of mice is used in many large-scale and more focused projects to generate and identify novel...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/65493
Source: American Journal of Physiology: Gastrointestinal and Liver Physiology
DOI: 10.1152/ajpgi.00343.2010

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