Random mutagenesis of the mouse genome: A strategy for discovering gene function and the molecular basis of disease
Mutagenesis of mice with N-ethyl-N-nitrosourea (ENU) is a phenotype-driven approach to unravel gene function and discover new biological pathways. Phenotype-driven approaches have the advantage of making no assumptions about the function of genes and their products and have been successfully applied to the discovery of novel gene-phenotype relationships in many physiological systems. ENU mutagenesis of mice is used in many large-scale and more focused projects to generate and identify novel...[Show more]
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|Source:||American Journal of Physiology: Gastrointestinal and Liver Physiology|
|01_Nguyen_Random_mutagenesis_of_the_2011.pdf||1.87 MB||Adobe PDF||Request a copy|
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