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Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation

Ajamieh, Hussam; Farrell, Geoffrey; Wong, Heng; Yu, Jun; Chu, Eagle; Chen, Jeffrey; Teoh, Narcissus


Background and Aim: Steatosis accentuates the severity of hepatic ischemia-reperfusion injury (IRI). 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors ("statins") protect the heart and brain against post-ischemic injury, without necessarily lowering serum cholesterol. We tested whether 10-day or 1-day atorvastatin administration protects livers with fatty change or non-alcoholic steatohepatitis (NASH) against IRI. Methods: Mice with dietary or genetic simple steatosis (SS) or NASH were...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Gastroenterology and Hepatology
DOI: 10.1111/j.1440-1746.2012.07123.x


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