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Disulfide bond acquisition through eukaryotic protein evolution

Wong, Jason W.H.; Ho, Simon; Hogg, Phillip


Disulfide bonds play critical roles in protein stability and function. They are generally considered to be strongly conserved among species. Although there is compelling evidence in the literature for this conservation on a case-by-case basis, comparative genomic analyses of disulfide conservation have in the past been limited. By analyzing the conservation of all structurally validated disulfide bonds from the Protein Data Bank across 29 completely sequenced eukaryotic genomes, we observe...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Molecular Biology and Evolution
DOI: 10.1093/molbev/msq194


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