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Recent and potential developments in the analysis of urine: A review

Ryan, Danielle; Robards, Kevin; Prenzler, Paul D; Kendall, Megan

Description

Analysis of urine is a widely used diagnostic tool that traditionally measured one or, at most, a few metabolites. However, the recognition of the need for a holistic approach to metabolism led to the application of metabolomics to urine for disease diagnostics. This review looks at various aspects of urinalysis including sampling and traditional approaches before reviewing recent developments using metabolomics. Spectrometric approaches are covered briefly since there are already a number of...[Show more]

dc.contributor.authorRyan, Danielle
dc.contributor.authorRobards, Kevin
dc.contributor.authorPrenzler, Paul D
dc.contributor.authorKendall, Megan
dc.date.accessioned2015-12-10T23:17:41Z
dc.identifier.issn0003-2670
dc.identifier.urihttp://hdl.handle.net/1885/65317
dc.description.abstractAnalysis of urine is a widely used diagnostic tool that traditionally measured one or, at most, a few metabolites. However, the recognition of the need for a holistic approach to metabolism led to the application of metabolomics to urine for disease diagnostics. This review looks at various aspects of urinalysis including sampling and traditional approaches before reviewing recent developments using metabolomics. Spectrometric approaches are covered briefly since there are already a number of very good reviews on NMR spectroscopy and mass spectrometry and other spectrometries are not as highly developed in their applications to metabolomics. On the other hand, there has been a recent surge in chromatographic applications dedicated to characterising the human urinary metabolome. While developments in the analysis of urine encompassing both classical approaches of urinalysis and metabolomics are covered, it must be emphasized that these approaches are not orthogonal - they both have their uses and are complementary. Regardless, the need to normalise analytical data remains an important impediment.
dc.publisherElsevier
dc.sourceAnalytica chimica acta
dc.subjectKeywords: Analytical data; Chromatographic application; Classical approach; Creatinine; Diagnostic tools; Disease diagnostics; Holistic approach; LC; Metabolomics; NMR spectroscopy; Normalisation; Urinary metabolome; Chromatography; Mass spectrometry; Metabolism; N Chromatography; Creatinine; LC; Normalisation; Spectrometry
dc.titleRecent and potential developments in the analysis of urine: A review
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume684
dc.date.issued2011
local.identifier.absfor110302 - Clinical Chemistry (diagnostics)
local.identifier.ariespublicationf2965xPUB1088
local.type.statusPublished Version
local.contributor.affiliationRyan, Danielle, Charles Sturt University
local.contributor.affiliationRobards, Kevin, Charles Sturt University
local.contributor.affiliationPrenzler, Paul D, Charles Sturt University
local.contributor.affiliationKendall, Megan, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue1-2
local.bibliographicCitation.startpage17
local.bibliographicCitation.lastpage29
local.identifier.doi10.1016/j.aca.2010.10.035
dc.date.updated2016-02-24T08:08:57Z
local.identifier.scopusID2-s2.0-78650175031
CollectionsANU Research Publications

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