The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes
He, Yiqing; Sutcliffe, Elissa L; Bunting, Karen; Li, Jasmine; Goodall, Katherine J.; Poon, Ivan K.A.; Hulett, Mark; Freeman, Craig; Zafar, Anjum; McInnes, Russell; Taya, Toshiki; Rao, Sudha; Parish, Christopher
The methylation of histones is a fundamental epigenetic process regulating gene expression programs in mammalian cells. Dysregulated patterns of histone methylation are directly implicated in malignant transformation. Here, we report the unexpected finding that the invasive extracellular matrix degrading endoglycosidase heparanase enters the nucleus of activated human T lymphocytes and regulates the transcription of a cohort of inducible immune response genes by controlling histone H3...[Show more]
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