Skip navigation
Skip navigation

The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes

He, Yiqing; Sutcliffe, Elissa L; Bunting, Karen; Li, Jasmine; Goodall, Katherine J.; Poon, Ivan K.A.; Hulett, Mark; Freeman, Craig; Zafar, Anjum; McInnes, Russell; Taya, Toshiki; Rao, Sudha; Parish, Christopher

Description

The methylation of histones is a fundamental epigenetic process regulating gene expression programs in mammalian cells. Dysregulated patterns of histone methylation are directly implicated in malignant transformation. Here, we report the unexpected finding that the invasive extracellular matrix degrading endoglycosidase heparanase enters the nucleus of activated human T lymphocytes and regulates the transcription of a cohort of inducible immune response genes by controlling histone H3...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/65279
Source: Transcription (Austin)
DOI: 10.4161/trns.19998

Download

File Description SizeFormat Image
01_He_The_endoglycosidase_heparanase_2012.pdf2.13 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator