Ossowski, Stephan; Schneeberger, Korbinian; Lucas-Lledó, José Ignacio; Warthmann, Norman; Clark, Richard M; Shaw, Ruth G; Weigel, Detlef; Lynch, Michael
To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and...[Show more]
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