Inhibition of bacterial RNA polymerase by the cyanobacterial metabolites 12- epi -hapalindole E isonitrile and calothrixin A
-
Altmetric Citations
Doan, N; Stewart, P R; Smith, Geoffrey D
Description
The alkaloid 12-epi-hapalindole E isonitrile, from a cyanobacterial Fischerella species, and the indolophenanthridine calothrixin A, from Calothrix, inhibited Escherichia coli RNA polymerase competitively with respect to ATP, and non-competitively with respect to UTP. The inhibition was dependent on the order of addition of the inhibitors. The KI values, with ATP as the variable substrate, were 1.3±0.2 mM and 0.23±0.11 mM, respectively. Based on comparisons with the sensitivity of whole cells...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2001 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/65183 |
Source: | FEMS Microbiology Letters |
DOI: | 10.1016/S0378-1097(01)00059-3 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Doan_Inhibition_of_bacterial_RNA_2001.pdf | 229.55 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator