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Inhibition of bacterial RNA polymerase by the cyanobacterial metabolites 12- epi -hapalindole E isonitrile and calothrixin A

Doan, N; Stewart, P R; Smith, Geoffrey D


The alkaloid 12-epi-hapalindole E isonitrile, from a cyanobacterial Fischerella species, and the indolophenanthridine calothrixin A, from Calothrix, inhibited Escherichia coli RNA polymerase competitively with respect to ATP, and non-competitively with respect to UTP. The inhibition was dependent on the order of addition of the inhibitors. The KI values, with ATP as the variable substrate, were 1.3±0.2 mM and 0.23±0.11 mM, respectively. Based on comparisons with the sensitivity of whole cells...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: FEMS Microbiology Letters
DOI: 10.1016/S0378-1097(01)00059-3


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