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Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease

Lawrance, I; Maxwell, Lesley; Doe, W


Background and Aims: Fibrosis is a major complication of inflammatory bowel disease (IBD), which may be mediated by the intestinal fibroblast. Our aim was to isolate and characterize mucosal fibroblasts from histologically normal intestine (control), ulcerative colitis (UC), inflamed Crohn's disease (CD), and fibrosed CD intestine. Methods: Fibroblasts were characterized by light and electron microscopy and immunohistochemistry. Fibroblast collagen secretion and proliferation were determined by...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Inflammatory Bowel Diseases


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