King, Karen; McCullagh, Peter
Background: The liability to overwhelming infection of children lacking a spleen either as a result of its congenital absence or because of splenectomy, has been frequently documented. Although there have been numerous studies of the consequences of experimental splenectomy in postnatal animals, this is the first study of the effects of this operation in early fetal life. Methods: A technique is described for microsurgical removal of the spleen from fetal lambs approximately one-third of the...[Show more]
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