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Effect of early fetal splenectomy on prenatal B-cell development in sheep

Press, C M; McCullagh, Peter; Landsverk, T


The contribution of early splenic B-cell populations to the colonization of the ileal Peyer's patch was investigated following the surgical removal of the spleen in a series of 56-day-old fetal sheep. The fetuses were killed at 140 days of gestation and the ileal Peyer's patch, the distal jejunal lymph node which drains the Peyer's patch, and a peripheral lymph node, the superficial cervical lymph node, were examined. Enzyme and immunohistochemical evaluation concluded that the distribution of...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Immunology
DOI: 10.1046/j.1365-2567.2001.01153.x


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