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Segregation of B Lymphocytes into Stationary Apoptotic and Migratory Proliferating Subpopulations in Agglomerate Cultures with Ileal Epithelium

Alitheen, N; McClure, Susan J; McCullagh, Peter


The B lymphocyte-epithelial cell interactions that define the microenvironment of the ileal Peyer's patch, the primary B lymphocyte organ of the fetal lamb, have been replicated in tissue culture. Mixed suspensions of ileal epithelial cells, lymphocytes and fibroblasts from fetuses of 63-103 days of gestation organized into macroscopically visible agglomerates within 72 h. These agglomerates contained translucent spherical cavities and were enclosed within a marginal cell layer and surrounded...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: European Journal of Immunology
DOI: 10.1002/1521-4141(200109)31:9<2558::AID-IMMU2558>3.0.CO;2-B


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