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A ''Neural'' Enzyme in Nonbilaterian Animals and Algae: Preneural Origins for Peptidylglycine a-Amidating Monooxygenase

Attenborough, Rosalind; Hayward, David; Kitahara, Marcelo V.; Miller, David J.; Ball, Eldon


Secreted peptides, produced by enzymatic processing of larger precursor molecules, are found throughout the animal kingdom and play important regulatory roles as neurotransmitters and hormones. Many require a carboxy-terminal modification, involving the conversion of a glycine residue into an α-amide, for their biological activity. Two sequential enzymatic activities catalyze this conversion: a monooxygenase (peptidylglycine α-hydroxylating monooxygenase or PHM) and an amidating lyase...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Molecular Biology and Evolution
DOI: 10.1093/molbev/mss114


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