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New insights into nucleosome and chromatin structure: An ordered state or a disordered affair?

Luger, Karolin; Mekonnen, Dechassa; Tremethick, David


The compaction of genomic DNA into chromatin has profound implications for the regulation of key processes such as transcription, replication and DNA repair. Nucleosomes, the repeating building blocks of chromatin, vary in the composition of their histone protein components. This is the result of the incorporation of variant histones and post-translational modifications of histone amino acid side chains. The resulting changes in nucleosome structure, stability and dynamics affect the compaction...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Nature Reviews: Molecular Cell Biology
DOI: 10.1038/nrm3382


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