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Extreme Telomere Length Dimorphism in the Tasmanian Devil and Related Marsupials Suggests Parental Control of Telomere Length

Bender, Hannah; Murchison, Elizabeth P.; Pickett, Hilda A.; Deakin, Janine; Strong, Margaret A.; Conlan (previously Smith), Carly; McMillan, Daniel; Neumann, Axel A.; Greider, Carol W.; Hannon, Gregory; Reddel, Roger R.; Graves, Jennifer

Description

Telomeres, specialised structures that protect chromosome ends, play a critical role in preserving chromosome integrity. Telomere dynamics in the Tasmanian devil (Sarcophilus harrisii) are of particular interest in light of the emergence of devil facial tumour disease (DFTD), a transmissible malignancy that causes rapid mortality and threatens the species with extinction. We used fluorescent in situ hybridisation to investigate telomere length in DFTD cells, in healthy Tasmanian devils and in...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/64877
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0046195

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