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Midbrain cleft as a cause of chronic internuclear ophthalmoplegia, progressive ataxia, and facial weakness

Ahmad, Omar; Reddel, Stephen; Lueck, Christian


A 44-year-old man with progressive ataxia, facial weakness, bilateral adduction deficits, and abducting nystagmus was initially misdiagnosed and treated for multiple sclerosis because a midbrain anatomic cleft had been overlooked on brain MRI. Six cases of "midbrain (or mesencephalic) cleft" or "keyhole aqueduct syndrome" have been previously reported. This developmental anatomic abnormality always manifests bilateral internuclear ophthalmoplegia (INO), often together with ataxia, which may be...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Neuro-Ophthalmology
DOI: 10.1097/WNO.0b013e3181da2ceb


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