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A Comparative Genomics Approach to Understanding Transmissible Cancer in Tasmanian Devils

Deakin, Janine; Belov, Katherine

Description

A fatal contagious cancer is driving an entire species to extinction. Comparative genomics will unravel the origin and evolution of devil facial tumor disease (DFTD). The DFTD allograft arose from a Schwann cell in a female Tasmanian devil more than 15 years ago; since then, the tumor has passed through at least 100,000 hosts, evolving and mutating along the way. Tumor genome sequencing and molecular cytogenetic technologies now allow direct comparisons of candidate genes involved in...[Show more]

dc.contributor.authorDeakin, Janine
dc.contributor.authorBelov, Katherine
dc.date.accessioned2015-12-10T23:15:53Z
dc.identifier.issn1527-8204
dc.identifier.urihttp://hdl.handle.net/1885/64833
dc.description.abstractA fatal contagious cancer is driving an entire species to extinction. Comparative genomics will unravel the origin and evolution of devil facial tumor disease (DFTD). The DFTD allograft arose from a Schwann cell in a female Tasmanian devil more than 15 years ago; since then, the tumor has passed through at least 100,000 hosts, evolving and mutating along the way. Tumor genome sequencing and molecular cytogenetic technologies now allow direct comparisons of candidate genes involved in tumorigenesis in human cancers. As a stable transmissible cancer, DFTD provides unique insights into cancer development, progression, and immune evasion and is likely to help increase our understanding of human cancer. In addition, these studies provide hope for discoveries of drug targets or vaccine candidates that will prevent the extinction of this iconic Australian marsupial.
dc.publisherAnnual Reviews Inc
dc.sourceAnnual Review of Genomics and Human Genetics
dc.subjectKeywords: animal; animal disease; Australia; comparative study; DNA sequence; endangered species; face tumor; genetics; genome; human; immunology; marsupial; population genetics; review; tumor escape; Animals; Endangered Species; Facial Neoplasms; Genetics, Populat
dc.titleA Comparative Genomics Approach to Understanding Transmissible Cancer in Tasmanian Devils
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume13
dc.date.issued2012
local.identifier.absfor060408 - Genomics
local.identifier.ariespublicationu9511635xPUB1005
local.type.statusPublished Version
local.contributor.affiliationDeakin, Janine, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBelov, Katherine, University of Sydney
local.description.embargo2037-12-31
local.bibliographicCitation.startpage207
local.bibliographicCitation.lastpage222
local.identifier.doi10.1146/annurev-genom-090711-163852
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2016-02-24T12:02:57Z
local.identifier.scopusID2-s2.0-84872934362
local.identifier.thomsonID000310143800009
CollectionsANU Research Publications

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