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A Comparative Genomics Approach to Understanding Transmissible Cancer in Tasmanian Devils

Deakin, Janine; Belov, Katherine

Description

A fatal contagious cancer is driving an entire species to extinction. Comparative genomics will unravel the origin and evolution of devil facial tumor disease (DFTD). The DFTD allograft arose from a Schwann cell in a female Tasmanian devil more than 15 years ago; since then, the tumor has passed through at least 100,000 hosts, evolving and mutating along the way. Tumor genome sequencing and molecular cytogenetic technologies now allow direct comparisons of candidate genes involved in...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/64833
Source: Annual Review of Genomics and Human Genetics
DOI: 10.1146/annurev-genom-090711-163852

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