Zinc fingers of the cerebellum (Zic): Transcription factors and co-factors
The Zic genes encode zinc finger containing proteins that can bind proteins and DNA. The understanding of Zic molecular networks has been hampered by functional redundancy amongst family members, and because their loss-of-function phenotypes are indicative of a role in many signalling pathways. Recently molecular evidence has emerged confirming the pleiotropic nature of these proteins: they act both as classical transcription factors and as co-factors to directly and indirectly influence gene...[Show more]
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|Source:||The International Journal of Biochemistry and Cell Biology|
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