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Membrane Transport in the Malaria-Infected Erythrocyte

Kirk, Kiaran

Description

The malaria parasite is a unicellular eukaryotic organism which, during the course of its complex life cycle, invades the red blood cells of its vertebrate host. As it grows multiplies within its host blood cell, the parasite modifies the membrane permeability cytosolic composition of the host cell. The intracellular parasite is enclosed within a so-called parasitophorous vacuolar membrane, tubular extensions of which radiate out into the host cell compartment. Like all eukaryote cells, the...[Show more]

dc.contributor.authorKirk, Kiaran
dc.date.accessioned2015-12-10T23:15:42Z
dc.identifier.issn0031-9333
dc.identifier.urihttp://hdl.handle.net/1885/64755
dc.description.abstractThe malaria parasite is a unicellular eukaryotic organism which, during the course of its complex life cycle, invades the red blood cells of its vertebrate host. As it grows multiplies within its host blood cell, the parasite modifies the membrane permeability cytosolic composition of the host cell. The intracellular parasite is enclosed within a so-called parasitophorous vacuolar membrane, tubular extensions of which radiate out into the host cell compartment. Like all eukaryote cells, the parasite has at its surface a plasma membrane, as well as having a variety of internal membrane-bound organelles that perform a range of functions. This review focuses on the transport properties of the different membranes of the malaria-infected erythrocyte, as well as on the role played by the various membrane transport systems in the uptake of solutes from the extracellular medium, the disposal of metabolic wastes, the origin maintenance of electrochemical ion gradients. Such systems are of considerable interest from the point of view of antimalarial chemotherapy, both as drug targets in their own right as routes for targeting cytotoxic agents into the intracellular parasite.
dc.publisherAmerican Physiological Society
dc.sourcePhysiological Reviews
dc.subjectKeywords: adenosine diphosphate; adenosine triphosphate; amino acid; antimalarial agent; calcium; chloride; chloroquine; choline; cytotoxic agent; lactic acid; magnesium; mefloquine; nucleoside; peptide; potassium; proton; sodium; sugar; vitamin; cell composition;
dc.titleMembrane Transport in the Malaria-Infected Erythrocyte
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume81
dc.date.issued2001
local.identifier.absfor060502 - Infectious Agents
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.ariespublicationMigratedxPub993
local.type.statusPublished Version
local.contributor.affiliationKirk, Kiaran, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage495
local.bibliographicCitation.lastpage537
dc.date.updated2015-12-10T09:47:03Z
local.identifier.scopusID2-s2.0-0035069258
CollectionsANU Research Publications

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