Anisimov, Victor M; Bliznyuk, Andrei
In this work, we present the results of a large-scale, semiempirical LocalSCF quantum mechanical study of GroEL-GroES chaperonin in solution containing 2-481-723 atoms. We find that large biological systems exhibit strong quantum mechanical character, the extent of which was not previously known. Our data show that protein transfers -743 electron units of charge to solvent, which is not described by classical force fields. Contrary to the commonly held belief, which is based on classical...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.