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EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response

Henderson, Michelle; Russell, Amanda; Hird, Samantha; Munoz, Marcia; Clancy, Jennifer; Lehrbach, Gillian M; Calanni, Sophina; Jans, David A; Sutherland, Robert L; Watts, Colin K


The ubiquitin-protein ligase EDD encodes an orthologue of the hyperplastic discs tumor suppressor gene, which has a critical role in Drosophila development. Frequent allelic imbalance at the EDD chromosomal locus in human cancers suggests a role in tumorigenesis. In addition to a HECT (homologous to E6-AP carboxyl terminus) domain, the EDD protein contains a UBR1 zinc finger motif and ubiquitin-associated domain, each of which indicates involvement in ubiquitinylation pathways. This study shows...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M203527200


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