EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response
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Henderson, Michelle; Russell, Amanda; Hird, Samantha; Munoz, Marcia; Clancy, Jennifer; Lehrbach, Gillian M; Calanni, Sophina; Jans, David A; Sutherland, Robert L; Watts, Colin K
Description
The ubiquitin-protein ligase EDD encodes an orthologue of the hyperplastic discs tumor suppressor gene, which has a critical role in Drosophila development. Frequent allelic imbalance at the EDD chromosomal locus in human cancers suggests a role in tumorigenesis. In addition to a HECT (homologous to E6-AP carboxyl terminus) domain, the EDD protein contains a UBR1 zinc finger motif and ubiquitin-associated domain, each of which indicates involvement in ubiquitinylation pathways. This study shows...[Show more]
Collections | ANU Research Publications |
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Date published: | 2002 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/64590 |
Source: | Journal of Biological Chemistry |
DOI: | 10.1074/jbc.M203527200 |
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File | Description | Size | Format | Image |
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01_Henderson_EDD,_the_Human_Hyperplastic_2002.pdf | 1.02 MB | Adobe PDF |
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